Download e-book for kindle: A Handbook for DNA-Encoded Chemistry: Theory and by Robert A. Goodnow Jr.

By Robert A. Goodnow Jr.

ISBN-10: 1118487680

ISBN-13: 9781118487686

This e-book comprehensively describes the advance and perform of DNA-encoded library synthesis expertise. jointly, the chapters element an method of drug discovery that provides an enticing addition to the portfolio of current hit new release applied sciences corresponding to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a worthy consultant for figuring out and making use of DNA-encoded combinatorial chemistry
  • Helps chemists generate and display novel chemical libraries of huge dimension and caliber
  • Bridges interdisciplinary components of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists the best way to successfully increase on hand “chemical house” for drug discovery
  • Provides specialist and up to date precis of mentioned literature for DNA-encoded and DNA-directed chemistry expertise and methods

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Additional resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

Example text

This function of a polymerase is also known as 3′ to 5′ exonuclease activity, and it explains the high fidelity that may be achieved by DNA replication. For the purpose of in vitro DNA amplification, a variety of thermostable template-dependent polymerases are utilized. The most well-known example is Taq polymerase [9], isolated from the bacterium Thermus aquaticus found in thermal springs. Taq polymerase has optimal activity between 75°C and 80°C [10]. Due to their heat resistance, Taq polymerase and other thermostable DNA polymerases are widely used in the Polymerase Chain Reaction, abbreviated PCR, a molecular biology technique employed in DNA amplification.

NAD+-dependent ligases are found only in bacteria, while eukaryotes and bacteriophages require ATP. T4 DNA ligase, isolated from T4 bacteriophage, has been extensively used in many molecular biology applications such as cloning and DEL technology. 5 to 8. Cohesive-end ligations are typically performed at room temperature or below to stabilize the transiently annealed oligonucleotide junctions, although the optimum temperature for the ligase itself is higher. T4 DNA ligase utilizes ATP as a cofactor.

34, e22. 28. , Kim, D. , Marma, M. , Edwards, J. , Turro, N. J. (2006). Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators. Proc. Natl. Acad. Sci. U. S. , 103, 19635–19640. 29. , Tairi, A. P. (2008). A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis. , 36, e25. 30. , Altman W. , Bader, J. , Bemben, L. , Braverman, M. , Chen, Y. , Dewell, S. , Fierro, J. , Gomes, X.

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A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery by Robert A. Goodnow Jr.


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