Analogue-Based Drug Discovery III - download pdf or read online

By Janos Fischer, C. Robin Ganellin, David P. Rotella

ISBN-10: 3527330739

ISBN-13: 9783527330737

ISBN-10: 352765108X

ISBN-13: 9783527651085

Such a lot medications are analogue medicines. There are not any basic principles how a brand new drug may be stumbled on, however, there are a few observations which support to discover a brand new drug, and likewise anyone tale of a drug discovery can start up and aid new discoveries. quantity III is a continuation of the winning publication sequence with new examples of verified and lately brought medications.
the main a part of the e-book is written via key inventors both as a case learn or a research of an analogue type. With its wide selection throughout quite a few healing fields and chemical periods, this is often of curiosity to almost each researcher in drug discovery and pharmaceutical chemistry, and -- including the former volumes -- constitutes the 1st systematic method of drug analogue development.Content:
Chapter 1 Pioneer and Analogue medicinal drugs (pages 1–19): Prof. Dr. Janos Fischer, Prof. Dr. C. Robin Ganellin and Prof. Dr. David P. Rotella
Chapter 2 festival within the Pharmaceutical Drug improvement (pages 21–35): Christian Tyrchan and Fabrizio Giordanetto
Chapter three Metabolic balance and Analogue?Based Drug Discovery (pages 37–75): Amit S. Kalgutkar and Antonia F. Stepan
Chapter four Use of Macrocycles in Drug layout Exemplified with Ulimorelin, a possible Ghrelin Agonist for Gastrointestinal Motility issues (pages 77–110): Dr. Mark L. Peterson, Dr. Hamid Hoveyda, Dr. Graeme Fraser, Eric Marsault and Rene Gagnon
Chapter five the invention of Anticancer medications focusing on Epigenetic Enzymes (pages 111–139): A. Ganesan
Chapter 6 Thienopyridyl and Direct?Acting P2Y12 Receptor Antagonist Antiplatelet medications (pages 141–164): Dr. Joseph A. Jakubowski and Atsuhiro Sugidachi
Chapter 7 Selective Estrogen Receptor Modulators (pages 165–185): Amarjit Luniwal, Rachael Jetson and Paul Erhardt
Chapter eight Discovery of Nonpeptide Vasopressin V2 Receptor Antagonists (pages 187–209): Kazumi Kondo and Hidenori Ogawa
Chapter nine the advance of Cysteinyl Leukotriene Receptor Antagonists (pages 211–239): Peter R. Bernstein
Chapter 10 the invention of Dabigatran Etexilate (pages 241–267): Norbert Hauel, Andreas Clemens, Herbert Nar, Henning Priepke, Joanne van Ryn and Wolfgang Wienen
Chapter eleven the invention of Citalopram and Its Refinement to Escitalopram (pages 269–294): Klaus P. Bogeso and Connie Sanchez
Chapter 12 Tapentadol – From Morphine and Tramadol to the invention of Tapentadol (pages 295–318): Helmut Buschmann
Chapter thirteen Novel Taxanes: Cabazitaxel Case research (pages 319–341): Dr. Herve Bouchard, Dr. Dorothee Semiond, Dr. Marie?Laure Risse and Dr. Patricia Vrignaud
Chapter 14 Discovery of Boceprevir and Narlaprevir: A Case learn for position of Structure?Based Drug layout (pages 343–363): Srikanth Venkatraman, Andrew Prongay and George F. Njoroge
Chapter 15 A New?Generation Uric Acid creation Inhibitor: Febuxostat (pages 365–376): Ken Okamoto, Shiro Kondo and Takeshi Nishino

Show description

Read Online or Download Analogue-Based Drug Discovery III PDF

Best pharmacy books

New PDF release: Fischer Cancer Chemotherapy Handbook

Here is a accomplished, but compact and useful advisor to the care and chemotherapeutic therapy of melanoma sufferers. It encompasses all significant chemotherapeutic brokers and combos, investigational and newly authorized medicines, and describes their mechanisms of motion, symptoms, metabolism, dose, management, toxicity, and drug interactions and incompatibilities.

Download PDF by Lilian M. Azzopardi: MCQs in Pharmacy Practice, 2nd Edition

This publication is designed as a revision relief, and covers subject matters as a rule featured in pharmacy undergraduate registration and licensing a number of selection examinations. This e-book is a perfect revision advisor for these getting ready to take a seat a a number of selection Questions (MCQs) exam in pharmacy. It covers universal basic pharmacy perform interventions and operations and different themes more often than not featured in examinations reminiscent of basic pharmaceutical calculations, doses, strengths, nomenclature, abbreviations, dosage varieties, specialties, exchange and customary names, biochemical assessments, type, side-effects, and customary illnesses.

Read e-book online Gene Profiles in Drug Design PDF

With the winning mapping of the human genome, we've entered an age of unheard of chance within which researchers are commencing to observe this large repository of information to the remedy of human illness. Gene-profiling applied sciences and the idea that of individualized drugs are resulting in the advance of substances with greater specificity.

Read e-book online Foundation in Pharmacy Practice PDF

This can be an introductory assessment to pharmacy perform. This introductory assessment to pharmacy perform is key for first yr undergraduate scholars, supplying an summary of the critical pharmacy perform themes in a realistic and succinct demeanour. The textual content presents a place to begin for additional learn and is facilitated through common signposting and referencing to precise texts.

Additional resources for Analogue-Based Drug Discovery III

Sample text

J. (1985) Substituted fused imidazole compounds as aromatase inhibitors. European Patent Application EP 165904A2. F. (1985) Imidazo[1,5-a] pyridines: a new class of thromboxane A2 synthetase inhibitors. J. Med. , 28, 164. , and Dukes, M. (1994) Arimidex: a potent and selective fourth-generation aromatase inhibitor. Breast Cancer Res. , 30, 103–111. N. (2006) A partial view of the quest for Arimidex, a potent, selective inhibitor of aromatase, in Smith and Williams’ Introduction to the Principles of Drug Design and Action, 4th edn, CRC Press, Boca Raton, FL, pp.

Lancet, 2 (7251), 311–314. C. (1964) A new adrenergic beta-receptor antagonist. Lancet, 1 (7342), 1080–1081. , and Le Count, D. (1973) A new type of cardioselective adrenoceptive blocking drug. Br. J. , 48, 3408. , and Friderichs, E. (1978) Studies of chemical structure and analgetic activity of phenyl substituted aminomethylcyclohexanoles. , 28 (I), 107–113. , and Friderichs, F. (2001) 1-Phenyl-3dimethylaminopropane compounds with a pharmacological effect. EP 693 475. Schmutz, J. and Eichenberger, E.

3 Multitarget Drugs discovery of citalopram and its refinement to escitalopram is discussed in Chapter 11. H N CH3 O F3C fluoxetine 30 NC CH3 O N CH3 F citalopram 31 N CH3 O H3C diphenhydramine (lead for fluoxetine) 32 H3C CH3 O NHCH3 talopram (lead for citalopram) 33 Summary: Pioneer multitarget nonselective serotonin/norepinephrine reuptake inhibitor antidepressant drug: imipramine. First (but unsuccessful) selective serotonin reuptake inhibitor: zimelidine. First selective serotonin reuptake inhibitors: fluoxetine and citalopram.

Download PDF sample

Analogue-Based Drug Discovery III by Janos Fischer, C. Robin Ganellin, David P. Rotella

by Steven

Rated 4.65 of 5 – based on 38 votes