Get Analysis of Single-Cell Data : ODE Constrained Mixture PDF

By Carolin Loos

ISBN-10: 3658132337

ISBN-13: 9783658132330

ISBN-10: 3658132345

ISBN-13: 9783658132347

Carolin bathrooms introduces novel methods for the research of single-cell information. either techniques can be utilized to review mobile heterogeneity and for that reason enhance a holistic figuring out of organic strategies. the 1st technique, ODE restricted combination modeling, allows the id of subpopulation buildings and assets of variability in single-cell picture information. the second one technique estimates parameters of single-cell time-lapse information utilizing approximate Bayesian computation and is ready to make the most the temporal cross-correlation of the information in addition to lineage info.

Show description

Read Online or Download Analysis of Single-Cell Data : ODE Constrained Mixture Modeling and Approximate Bayesian Computation PDF

Similar analysis books

Database Concurrency Control: Methods, Performance, and by Alexander Thomasian (auth.) PDF

Database Concurrency regulate: equipment, functionality and research is a evaluation of advancements in concurrency keep watch over tools for centralized database platforms, with a brief digression into dispensed databases and multicomputers, the emphasis being on functionality. the most objectives of Database Concurrency keep an eye on: tools, Performanceand research are to succinctly specify numerous concurrency regulate tools; to explain versions for comparing the relative functionality of concurrency keep an eye on equipment; to indicate areas of difficulty in prior functionality analyses; to introduce queuing community types to guage the baseline functionality of transaction processing structures; to supply insights into the relative functionality of transaction processing structures; to demonstrate the applying of simple analytic the right way to the functionality research of varied concurrency keep an eye on equipment; to study transaction types that are meant to alleviate the influence of lock rivalry; to supply guidance for bettering the functionality of transaction processing structures because of concurrency regulate; and to indicate parts for additional research.

Get From Data and Information Analysis to Knowledge Engineering: PDF

This quantity collects revised types of chosen papers offered in the course of the twenty ninth Annual convention of the Gesellschaft f? r Klassifikation (GfKl), the German category Society, held on the Otto-von-Guericke-University of Magdeburg, Germany, in March 2005. as well as papers on conventional matters equivalent to category, Clustering, and information research, there are numerous papers on a variety of subject matters with a robust relation to desktop technological know-how: textual content Mining, net Mining, Fuzzy info research, IT protection, Adaptivity and Personalization, and Visualization.

Download e-book for kindle: Image Analysis and Processing – ICIAP 2013: 17th by Abdenour Hadid, Mohammad Ghahramani (auth.), Alfredo

This quantity set (LNCS 8156 and 8157) constitutes the refereed lawsuits of the seventeenth overseas convention on photo research and Processing, ICIAP 2013, held in Naples, Italy, in September 2013. The 162 papers awarded have been conscientiously reviewed and chosen from 354 submissions. The papers goal at highlighting the relationship and synergies of picture processing and research with development acceptance and laptop studying, human desktops, biomedical imaging and functions, multimedia interplay and processing, 3D laptop imaginative and prescient, and knowing gadgets and scene.

Extra info for Analysis of Single-Cell Data : ODE Constrained Mixture Modeling and Approximate Bayesian Computation

Sample text

13A-C. The model can explain the data quite well. 13D shows that information is gained by using both measurements at the same time. We presented a method, which considers multivariate measurements simultaneously to infer parameters. This allows to capture correlated behavior between the measurements, which would not be possible if the measurements are considered separately. More information can be extracted from the data yielding higher confidence in the estimates.

The red circles mark the value of the loglikelihood function corresponding to the ML estimate. (A, B) show the optimizer output for the robust calculation. (A) All (local) optima found by the optimizer. (B) The best log-likelihood value is found in 71 out of 100 runs. The difference of the values is below 10−10 . (C) Only 1 initial value of 100 has a probabilty greater than 0 using the classical calculation. 2, comprising the conversion between two species A and B. Artificial Data As we want to analyze multivariate data, we measure both species A and B.

This is achieved by modeling subpopulation dynamics with RREs and treating different subpopulations as individual components of a mixture distribution. Combining these two approaches, the method benefits from both, the possibility to include distributional information and from getting mechanistic insights using ODEs. Using ODE-MMs, population snapshot data can be analyzed across different experimental conditions. Moreover, it has been shown that even the causal differences between subpopulations can be revealed.

Download PDF sample

Analysis of Single-Cell Data : ODE Constrained Mixture Modeling and Approximate Bayesian Computation by Carolin Loos


by William
4.4

Rated 4.58 of 5 – based on 5 votes