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For 24 - 72 hours and then slowly increase interval Page 63 Ch apte r 1 3 : Gas tr o i n te s ti n al I n fe c ti o n s H e l i c o bac te r p y l o r i - as s o c i ate d pe p ti c u l c e r ati o n / g a s tr i ti s All patients with peptic ulceration who are also infected with H. pylori should receive antibiotic therapy. The diagnosis of H. pylori infection is best made by histological examination of gastric antral biopsy samples. Effective treatment regimens include a proton pump inhibitor plus at least two antibiotics: Omeprazole 20 mg 12 hourly OR Lansoprazole 30 mg once daily PLUS Amoxycillin 1000 mg 12 hourly OR Metronidazole 400 mg 12 hourly PLUS Clarithromycin 500 mg 12 hourly All agents should be given for 7 days.

2 mU IM should be administered once monthly for 2 - 3 years after splenectomy. Alternative antibiotic chemotherapy includes penicillin V 250 mg PO 12 hourly daily (125 mg PO 12 hourly in children less than 5 years). For sophisticated patients, the “amoxycillin in pocket” approach is recommended; patients take amoxycillin 250 mg 8 hourly at the first sign of an upper respiratory tract infection. Rh e u m ati c fe v e r Chemoprophylaxis is usually started after the first episode of rheumatic fever and continued for 5 years, or up to the age of 18 years, which ever is the longer.

Cefazolin 1 - 2 g 8 hrly). Open reduction of fracture 1st generation cephalosporin eg. cefazolin 1 - 2 g IV pre-op. Laminectomy, spinal fusion Prophylactic antibiotics have not been proved to be beneficial. Lower limb amputation 1st generation cephalosporins eg. cefazolin 1 - 2 g IV. OR cefoxitin 2 g IV. g. hip surgery), but is dictated by high incidence of resistance to the 1st generation cephalosporins. • Data regarding prophylactic antibiotics in arthroscopic surgery is not available. Page 38 • 4.

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Antibiotic Guideline

by Christopher

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