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By W. A. Hemmings (auth.), W. A. Hemmings (eds.)

ISBN-10: 9401166099

ISBN-13: 9789401166096

ISBN-10: 9401166110

ISBN-13: 9789401166119

w. A. HEMMINGS the idea that proteins can input cells complete is a tough one. but the version occasions wherein this technique will be studied were recognized and investigated for a few years. these occasions come up throughout the specialization required to move immunoglobulins synthesized by means of the mum to the move of the fetus or child animal, that's within the transmission of passive immunity to the younger. This regularly involves the protein crossing a continuing mobile barrier, within the placenta or fetal membranes, or within the intestinal epithelium. the idea that is tough to just accept by way of telephone biology since it is tough to envisage a mechanism wherein proteins can cross in volume a cellphone membrane that's regulating the access of solutes. Brambell has recommend an speculation of one of these mechanism, restating it in 'The transmission of passive immunity from mom to younger' in 1970. In 1974, after his loss of life, a symposium was once held in Bangor mostly in this topic, released as 'Maternofetal Transmission of Immunoglobulins' . when you consider that then additional conferences were hung on intestine move below the name of the current quantity, which consists of papers drawn from those meetings.

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W. A. HEMMINGS the concept proteins can input cells entire is a tough one. but the version events wherein this method can be studied were recognized and investigated for a few years. these events come up during the specialization required to move immunoglobulins synthesized by means of the mummy to the move of the fetus or baby animal, that's within the transmission of passive immunity to the younger.

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Osmium tetroxide fixation . x 24000 Figure 10 Ileal section of a ferritin fed adult rat. Ferritin can be seen in the lumen, and also in the region of the terminal web. The protein is contained mainly in membrane bound vacuoles. Osmium tetroxide fixation.

These studies include quantitative observations of a preliminary nature by use of immunological methods, and ultrastructural findings on the transmission of ferritin using the electronmicroscope. MATERIALS AND METHODS In these investigations, six in vivo experiments were carried out using 260-300 g albino rats of the Wistar strain bred in this laboratory. They were allowed free access to food and water. Laparotomy was carried out under Nembutal and ether anaesthetic. A midline incision, about 5 cm long was made in the abdomen, and the whole gut gently pulled through to expose the duodenal and ileocaecal end of the ileum, a cut was made at this lower end, and the whole intestine was washed through with 30 ml phosphate buffered saline pH 8 from as near the pyloric end as was possible.

Am. J. , 123,227 Halliday, R. (1955). The absorption of antibodies from immune sera by the gut of the young rat. Proc. R. Soc. B, 143, 408 Halliday, R. (1959). The effect of steroid hormones on the absorption of antibodies by the young rat. J. , 18, 56 Jones, E. A. and Waldmann, T. A. (1972). The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J. , 51, 2916 Jones, R. E. (1972). Intestinal absorption and gastro-intestinal digestion of protein in young rats during the normal and cortisone-induced post-closure period.

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Antigen Absorption by the Gut by W. A. Hemmings (auth.), W. A. Hemmings (eds.)

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