By Junhua (Alex) Tao, Guo-Qiang Lin, Andreas Liese
Biocatalysis is quickly evolving right into a key expertise for the invention and creation of chemical compounds, particularly within the pharmaceutical undefined, the place excessive yielding chemo-, regio-, and enantioselective reactions are serious. Taking the newest breakthroughs in genomics and proteomics into account, Biocatalysis for the Pharmaceutical Industry concisely but comprehensively discusses the trendy software of biocatalysis to drug discovery, improvement, and production. Written by way of a staff of prime specialists, the e-book bargains deep perception into this leading edge box.
- Covers quite a lot of issues in a scientific demeanour with an emphasis on commercial functions
- Provides an intensive creation to the most recent biocatalysts, smooth expression hosts, cutting-edge directed evolution, excessive throughput screening, and bioprocess engineering
- Addresses frontier matters akin to rising enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and independent enzymes for the synthesis and improvement of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and common product analogs
- Highlights the effect of biocatalysis on eco-friendly chemistry
- Contains various snap shots to demonstrate ideas and methods
Biocatalysis for the Pharmaceutical Industry is a necessary source for scientists, engineers, and R&D coverage makers within the nice chemical, pharmaceutical, and biotech industries. it's also a useful instrument for educational researchers and complicated scholars of natural and fabrics synthesis, chemical biology, and medicinal chemistry.Content:
Chapter 1 Enzymes and Their artificial purposes: an outline (pages 1–19): Junhua (Alex) Tao and Jian?He Xu
Chapter 2 Expression Hosts for Enzyme Discovery and creation (pages 21–44): Aleksandra Andryushkova and Anton Glieder
Chapter three Directed Enzyme Evolution and High?Throughput Screening (pages 45–64): Michael J. McLachlan, Ryan P. Sullivan and Huimin Zhao
Chapter four functions of response Engineering to commercial Biotransformations (pages 65–88): Lutz Hilterhaus and Andreas Liese
Chapter five Chiral Synthesis of Pharmaceutical Intermediates utilizing Oxynitrilases (pages 89–109): Wen?Ya Lu and Guo?Qiang Lin
Chapter 6 increasing the Scope of Aldolases as instruments for natural Synthesis (pages 111–119): William A. Greenberg
Chapter 7 man made purposes of Ketoreductases and Alcohol Oxidases (pages 121–151): Dunming Zhu and Ling Hua
Chapter eight purposes of Nitrile Hydratases and Nitrilases (pages 153–181): Grace DeSantis and Robert DiCosimo
Chapter nine Biosynthesis of Drug Metabolites (pages 183–211): Wenying Li, David Rozzell, Spiros Kambourakis and Martin Mayhew
Chapter 10 software of Whole?Cell Biotransformation within the Pharmaceutical (pages 213–227): family Sing Lam
Chapter eleven Combinatorial Biosynthesis of Pharmaceutical ordinary items (pages 229–245): Wen Liu and Yi Yu
Chapter 12 Metabolic Engineering for the improvement and production of prescription drugs (pages 247–271): Dongping Lu, Philip G. Williams and Guangyi Wang
Chapter thirteen Multimodular Synthases and helping Enzymes for Chemical creation (pages 273–303): Michael Burkart and Junhua (Alex) Tao
Chapter 14 eco-friendly Chemistry with Biocatalysis for construction of prescription drugs (pages 305–321): Oliver might
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Extra resources for Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing
2005) Advanced genetic strategies for recombinant protein expression in Pichia pastoris. Journal of Biotechnology, 115 (2), 113–128. R. (2001) Advances in Pichia pastoris production of therapeutic proteins. Current Opinion in Biotechnology, 12 (2), 195–201.  Petsch, D. B. (2000) Endotoxin removal from protein solutions. Journal of Biotechnology, 76 (2–3), 97–119. H. Y. (2004) Secretory and extracellular production of recombinant proteins using Pichia pastoris. Applied Microbiology and Biotechnology, 64 (5), 625–635.
Polymorpha  is generally referred to as safe and was widely used for pharma-protein production (cytokines, vaccines, coagulation factors) . The genome sequence is known and DNA chip technologies have been established. Hansenula was developed to an expression platform which was implemented for the production of recombinant vaccines. P. pastoris was used for the production of several hundred proteins for industry and research needs , many of those being mammalian proteins. Recently, it was reported to produce humanized IgG in a glycoengineered strain .
This does not occur in humans. Yeasts are generally inclined to hyperglycosylate secreted proteins because in this way they produce proteins for their cell wall, but this is most pronounced in S. cerevisiae  and less so in P. pastoris  and S. pombe . They do not add sialic acid, which is a typical finishing glycan decoration in human cells. Glycoproteins with terminal mannose are not very suitable for therapeutic purposes as they are quickly filtered from blood through the mammalian macrophage Man-receptor system.
Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing by Junhua (Alex) Tao, Guo-Qiang Lin, Andreas Liese