By Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.)
This booklet is the results of a global symposium held on the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The cause of this symposium used to be to supply a chance to check the knowledge on coronavirus constitution and copy tion in addition to to debate mechanisms of pathogenesis. For over a decade coronaviruses were well-known as an enormous workforce of viruses that are liable for various illnesses of scientific value in animals and guy. lately new and fascinating facts at the molecular biology and pathogenesis of coronaviruses became on hand and this led us to arrange this assembly. The uniformity and variety during this virus workforce was once evaluated from a molecular perspective and the replication of coronaviruses seems to contain features that could be special for this virus workforce. also, unlike different confident strand RNA viruses it turned transparent that coronaviruses easily identify continual infections within the host, a phenomenon that could bring about the various subacute or power problems manifested in the course of coronavirus an infection. This quantity provides a sequence of articles established upon the clinical presentation given on the symposium. furthermore, there are articles via B. W. J. Mahy and D. A. J. Tyrrell which summarize the present nation of artwork in regards to the biochemistry and biology of coronaviruses, respective ly. We think this e-book should be of curiosity to all virologists and especially to either tested staff and novices to this box. V.
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Additional info for Biochemistry and Biology of Coronaviruses
IBV, the only avian coronavirus to be extensively studied, has been shown to be antigenically unrelated to the mammalian coronaviruses (14,19), and thus apparently forms a separate antigenic group. The antigenic relationships between coronavirus species and strains within these species have been studied by enzyme-linked immunosorbent assay (ELISA). ELISA has been shown to be highly sensitive and to detect a broad range of antigenic specificity. The ELISA technique used has been described previously (5) using sucrose gradient purified antigens and immune sera to these antigens raised in rabbits (5).
In summary, we have shown that MS isolates SD and SK differ from human coronaviruses OC43 and 229E and mouse coronaviruses JHM and A59. However, coronaviruses A59, SO, SK, and OC43 al I share antigenic determinants. 1. REFERENCES Bonner, WM and Laskey, RA: A fi 1m detection method for tritiumlabeled proteins and nucleic acids in polyacrylamide gels. Eur. J. Biochem. 46:83-88, 1974. 2. Bradburne, AF: Antigenic relationships amongst coronaviruses. Arch. ges Virusforsch. 31:352-364, 1970. 3. Burks, JS, DeVald, BL, Jankovsky, LO, and Gerdes, JC: Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients.
1. Peaks of infectious virus were obtained at 24 hr, with a rapid decline occurring after this time indicating that the virus is highly labile. The growth of infectious virus was paralleled by the extracellular incorporation of labeled amino acids into TCA-precipitable material. 05. When additional vitamins and amino acids were not used, the yield was decreased by 300-fold. Preliminary amino acid analyses on purified virus showed 49 THE RNA AND PROTEINS . g ~6 E Hours of Incubation (post-adsorption) Fig.
Biochemistry and Biology of Coronaviruses by Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.)