New PDF release: Biochemistry of Platelets

By David R. Phillips

ISBN-10: 0125532407

ISBN-13: 9780125532402

ISBN-10: 0125532415

ISBN-13: 9780125532419

Show description

Read Online or Download Biochemistry of Platelets PDF

Best biochemistry books

Get Proteome Research. Concepts, Tech and Appln PDF

Proteomics is a multifaceted, interdisciplinary box which reviews the complexity and dynamics of proteins in organic platforms. It combines robust separation and analytical know-how with complicated informatics to appreciate the functionality of proteins within the mobile and within the physique. This publication offers a transparent conceptual description of every side of proteomics, describes contemporary advances in expertise and pondering in each one sector, and gives information of ways those were utilized to various organic difficulties.

Get Lysozymes: Model Enzymes in Biochemistry and Biology PDF

Greater than seventy years after Fleming's discovery of lysozyme, this enzyme maintains to play a very important position as a version enzyme in protein chemistry, enzymology, crystallography, molecular biology and genetics, immunology and in addition in evolutionary biology. The classical consultant of this frequent enzyme relations is the rooster egg-white lysozyme.

Download PDF by T. J. Franklin: Biochemistry of Antimicrobial Action

The fast advances made within the examine of the synthesis, constitution and serve as of organic macromolecules within the final fifteen years have enabled scientists eager about antimicrobial brokers to accomplish a substantial degree of figuring out of the way those components inhibit mobile development and department.

Additional resources for Biochemistry of Platelets

Sample text

The fact that 8-bromo cGMP can inhibit platelet functions also indicates that cGMP, as well as cAMP, is inhibitory. Takai et al. (1981b) reported that nitroprusside caused a rise in cGMP levels and a concomitant inhibition of production of diacyglycerol, phosphorylation of 40K protein, and secretion of serotonin in thrombin-stimulated platelets. These effects were accompanied by enhanced phosphorylation of a 50K protein. 8Bromo cGMP had a similar effect. Since dibutyryl cAMP also inhibits these platelet functions as well as stimulating phosphorylation of the 50K and other proteins, Takai et al.

Change in Intracellular pH A variety of cell functions have been shown to correlate with changes in intracellular pH (for background see proceedings of a symposium edited by Nuccitelli and Deamer, 1982), and Home et al. (1981) reported that thrombin caused an increase in platelet cytosolic pH, measured with fluorescent probes. The dose dependence and the time course of the change were consistent with a role in stimulus-response coupling, but the important cause-effect relationship has not been established nor have changes in response to other agonists been reported.

Decreased Levels of Cyclic AMP in Response to Platelet Stimulation Since elevated levels of cAMP inhibit platelet activation, does a reduction in the level of cAMP cause activation? , 1977; Haslam and Vanderwal, 1982), and ADP, epinephrine, thrombin, and PAF have been shown to inhibit adenylate cyclase activity in cell-free preparations (Cooper and Rodbell, 1979; Steer and Wood, 1979; Haslam and Vanderwal, 1982; Aktories and Jakobs, 1984). Other platelet agonists, such as vasopressin and the endoperoxide analogs U-46619 and U44069, however, can activate platelets but are unable to lower the elevated levels of cAMP (Haslam, 1975; Best et al, 1979), indicating that supression of cAMP levels is not a prerequisite for platelet activation.

Download PDF sample

Biochemistry of Platelets by David R. Phillips

by Jeff

Rated 4.90 of 5 – based on 21 votes