By Trudy McKee, James R. McKee
This textbook is for a various viewers starting from chemistry majors to scholars in any of the lifestyles sciences. The logical association - dialogue of molecular constitution instantly by means of the function it performs in metabolism - leads scholars throughout the advanced global of biochemistry whereas a magnificent paintings application is helping to lead them via up to date recommendations.
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106,2177-2181. 30. Traylor, TG. and R Xu (1988). Model reactions related to cytochrome P-450. Effects of alkene structure on the rates of epoxide formation. J. Am. Chem. Soc. 110, 1953-1958. 31. E. T. Groves (1988). Rearrangement of alkyl hydroperoxides mediated by cytochrome P-450: Evidence for the oxygen rebound mechanism. In J. J. Birkett, R. K. E. ). Microsomes and Drug Oxidations. Taylor and Francis, New York, pp. 176-183. 32. Y. J. A. Thompson (2001). Comparisons of hydroperoxide isomerase and monooxygenase activities of cytochrome P450 for conversions of allylic hydroperoxides and alcohols to epoxyalcohols and diols: Probing substrate reorientation in the active site.
As can be seen, this species is tantalizingly close to the oxidation potential of water/hydrogen peroxide at low pH. 8. Metalloporphyrins as Detectors and Decomposition Catalysts of Peroxynitrite The rapid reaction rates of peroxides with metalloporphyrins and the detection of observable oxometalloporphyrin species, especially in the reactions of manganese porphyrins with various oxidants (m-CPBA, NaOCl, KHS05)^^^ have also inspired the use of these porphyrins as detectors for a transient biological oxidant, perox5niitrite (ONOO~).
J. Inorg. Biochem. 83, 289-300. 16. Ortiz de Montellano, RR. ) (1995). Cytochrome P-450: Structure, Mechanism and Biochemistry, 2 edn. Plenum Press, New York. 17. Guengerich, ER (2001). Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem. Res. Toxicol. 14, 611-650. 18. Meunier, B. and J. Bernadou (2002). Metal-oxo species in P450 enzymes and biomimetic models. Oxo-hydroxo tautomerism with water-soluble metalloporphyrins. Top. Catal. 21, 47-54. 19. T. (2003).
Biochemistry. the molecular basis of life by Trudy McKee, James R. McKee