By Meir Shinitzky
An updated overview of simple study on biomembranes. during this quantity, greatest specialists within the box examine crucial points of sign transduction throughout organic membranes: - normal Mechanistic styles of sign Transduction - Receptors for Neurotransmitters and Peptide Hormones - G Proteins in sign Transduction - Membrane-associated Protein Kinases and Phosphatases - Phospholipases in sign Transduction the quantity is a wonderful complement to 'Biomembranes - actual features' and 'Biomembranes - Structural and sensible Aspects', additionally edited by way of Meir Shinitzky. those 3 books jointly supply a entire floor for figuring out advanced physiological techniques. Meir Shinitzky, Ph. D., is Professor of Biophysics within the division of Membrane learn and Biophysics, The Weizman Institute of technology, Rehovot, Israel. considering the fact that 1971, his examine has thinking about quite a few facets of membrane constitution and dynamics.
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Extra resources for Biomembranes, Singal Transduction Across Membranes
One of the most predominant substrates of PKC is the myristoylated alanine-rich C kinase substrate (MARCKS), which is a filamentous F-actin crosslinking protein and may be a PKC-regulated cross bridge between actin and the plasma membrane. Furthermore, it is clear that PKC plays a crucial role in the regulation of gene expression [50,69,70]. As a consequence of the phosphorylation of IKB,it can no longer associate with cytosolic NFKB,and the free NFKB translocates to the nucleus where it binds to specific response elements in the regulatory regions of genes leading to their enhanced expression.
Spaargaren 40 et al. tyrosine kinases. Another group of serinekhreonine kinases are, like PKC, second-messenger-activated kinases, such as PKA and CAMkinase, PKA being mainly involved in signal transduction by G-proteincoupled receptors that act on AC. Furthermore, it has recently been established that tyrosine kinases belonging to the src-family are involved in signal transduction by a number of cytokine receptors and also by some receptor tyrosine kinases. Below we discuss the properties and signal transduction relevance for some of these kinases in more detail.
At present approximately 18 different mammalian G-protein a subunits have been cloned [71,123] that can be classified into four subclasses based on amino acid similarity (Table 111): (1) The G, class consisting of the a, (having four splicing variants) and which is involved in olfaction; (2) The Gi the highly homologous aOlf class consisting of the highly homologous ail,a2 and ai3,aOA and aOB, M . Spaargaren et al. 28 GbP GbP GiP 4 Signal Fig. 13. Functioning of G-proteins in signal transduction.
Biomembranes, Singal Transduction Across Membranes by Meir Shinitzky