Get Bioquimica de Harper 14 Ed Harper's Biochemistry PDF

By Daryl K. Granner, Peter A. Mayes, Robert Murray

ISBN-10: 9684267568

ISBN-13: 9789684267565

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Extra info for Bioquimica de Harper 14 Ed Harper's Biochemistry

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La qufmica básica de la sintesis de los péptidos, desarrollada a fines del decenio de 1800 por el químico a l e m h Emil Fisisher, proporciona los elementos para la activaci6n de los grupos carboxilo y para la adición y eliminación de los grupos bloqueados, que evita reacciones colaterales indeseables. Muchos aAos despues, las tkcnicas de sintesis de los pbptidos fueron evolucionados por Bmce MerrifieEd (Premio Nobel 19841, quien desarrollb la síntesis en fase dlida. La tdcnica automeica de síntesis de Merrifield que produce ptptidos largos sintkticos en periodos cortos, inicib un renacimiento en la química de los péptidos.

Annu Rev Biophys Biophys Chem 1991;20:205. m, Strickler JE, W i b o n KJ: Contemporary methodology fos protein structure determination. Science 1984;226:304. Karger BL, Chy YH, Foret P: Capillary electrophoresis of proteins and nucleic acids. Annu Rev Biophys Biomol Struct 1995;24:579. Kent SBH: Chemical synthesis of peptides and proteins. Annu Rev Biochem 1988;57:957. Hunkapiller MerrifieEd RB: S o l i d phasc s y n t h e c i s . Science 19&6:232:341. Ozols J : Amino acid analysis. Methods Enzymol 1990;182 587 Regnier FE,Gooding KM: High performance liquid chromatography of proteins.

1' w : 3 . c E , . - do aspártic o Áci do glutamico ,inina imagina Cisi:eina Glic:ina G lutamina Histiclina Cisinia a -Serin. - encuentra en regiones donde tos pdptidos se doblan en forma aguda. as moldculas de agua de las proteinas que estan en la vecindad inmediata. Es tlpica la presencia de estos aminohcidos en el interior de proteinas citosólicas. Los grupos R con carga, de los aminoácidos básicos y acidicos, estabilizan las conformaciones proteínicas especificaspor intermedio de la formación de enlaces salinos.

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Bioquimica de Harper 14 Ed Harper's Biochemistry by Daryl K. Granner, Peter A. Mayes, Robert Murray

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