Read e-book online Burger's Medicinal Chemistry and Drug Discovery, Vol. 2: PDF

By Donald J. Abraham (ed.)

ISBN-10: 0471370282

ISBN-13: 9780471370284

This new quantity includes severe new chapters on Combinational Chemistry and a number of Parallel Synthesis, excessive Throughput Pharmacology, and Retrometabolism-Based Drug layout and concentrating on.

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Extra info for Burger's Medicinal Chemistry and Drug Discovery, Vol. 2: Drug Discovery and Drug Development

Example text

31. Illustration of fluorous phase methods in the synthesis of a mappacine library. One is disturbed to note also that in a few cases where a census has been taken of very large libraries, the wrong or missing structures are not statistically distributed (149). Thus, such libraries have a structural bias. For example, the chemistry may selectively favor production of more lipophilic substances so that hydrophilic examples are underrepresented. It is hard to see how to get around this conveniently.

Frank, P. V . Devasthale, E. J. Gentry, V . T . Ravikumar, A. , Comb. Chem. , 1, 89 (1998). 131. C. S. Lee, D. Allwine,M. R. Barbachyn, K. C. Grega, L. A. , Biorg. Med. , 9, 3243 (2001). 132. M. F. Gordeev, Curr. Opin. Drug Discov. , 4,450 (2001). 133. S. C. Bergmeier and S. J. Katz, J. Comb. , 4, 162 (2002). 134. M. Kidwai, P. Misra, K. R. Bhushan, R. K. Saxena, and M . Singh, Monatsh. , 131,937 (2000). 135. C. Zhang, S. Sarshar, E. J. Moran, S. Krane, J. C. Rodarte, K. D. , Biorg. Med. Chem. , 10,2603 (2000).

Acad. Sci. USA, 96,4330 (1999). 106. J . Jiracek, A. Yiotakis, B. Vincent, B. Checler, and V . Dive, J. Biol. , 271, 19606 (1996). 107. M. Bastos, N. J. Maeji, and R. H. Abeles, Proc. Natl. Acad. Sci. USA, 92,6738 (1995). 108. J. M . Salvino, R. Mathew, T . Kiesow, R. Narensingh, H. J. , Biorg. Med. Chem. , 10, 1637 (2000). 109. S. M. Dankwaardt, R. J. Billedeau, L. K. Lawley, S. C. Abbot, R. L. , Biorg. Med. Chem. , 10, 2513 (2000). 110. T. A. Rano, T . Timkey, E. P. Peterson, J . Rotonda, D. W .

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Burger's Medicinal Chemistry and Drug Discovery, Vol. 2: Drug Discovery and Drug Development by Donald J. Abraham (ed.)


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