By Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann, Prof. Dr. K. Greef, Prof. Dr. J. C. Skou (eds.)
The bicentenary of William Withering's now recognized clinical file entitled "An Account of the Foxglove and a few of its clinical makes use of" has given us the party to research the state-of-the-art. Cardiac glycosides in 1985 are thought of tobe the foundation for clinical therapy of myocardial failure, including diuretics and vasodilators within the extra serious instances. however, the debate as to their unique position within the remedy of center failure with sinus rhythm hasn't ever ceased. even supposing cardiac glycosides are of unquestionable worth in tachycardia because of atrial traumatic inflammation or atrial flutter, the persistent use of those medicines in sinus rhythm isn't often authorised. the advance of tolerance has been pronounced. it's of curiosity that Withering hirnself wrote: "-let it (foxglove) be endured until eventually it both acts at the kidneys, the tummy, the heartbeat, or the bowels; Iet or not it's stopped upon the 1st visual appeal of any of those results, and that i will preserve that the sufferer won't be afflicted by its exhibition, nor the practitioner be disillusioned in any average expectation. " In West Germany on my own, greater than 3 million sufferers (about five% of the entire inhabitants) are consistently taking cardiac glycosides. those medicinal drugs are the main prescribed medicaments in lots of nations. hence, we thought of it beneficial and essential to assessment in a serious approach modern-day wisdom in regards to the foxglove; to file new findings and to guage outdated Statements.
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Additional info for Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance
Takeda K, Temma K, Akera T (1982) J Pharmacol Exp Ther 222: 132-139 15. Temma K, Akera T, Brody TM (1981) Eur J Pharmacol 76: 361-370 16. Thomas G, Chung M, Cohen CJ (1985) Circ Res 56: 87-96 17. Yamamoto S, Akera T, Kim D-H, Brody TM (1981) J Pharmacol Exp Ther 217: 701-707 Author's adress: Prof. Dr. T. ) 27 Structural studies on the cardiac glycoside receptor1 E. T. Wallick, T. L. Kirley and A. ) Introduction The recent publication by Shull et al. (20) of the complete primary amino acid sequence of the alpha subunit of Na+ ,K+ -ATPase of sheep kidney allows investigators in the field to address questions of structure/function relationships more directly.
Results The inhibition by 50 ~-tM TNM of A TPase and pNPPase activities, as weil as maximal ouabain binding (MgPi binding conditions) of Na+, K+-ATPase does not follow first order reaction kinetics (Fig. 4) . As has been found with a variety of chemical modifiers, the order of susceptibility of activities is A TPase > pNPPase > ouabain binding. As determined by Scatchard analysis , the tetranitromethane-induced decrease in ouabain binding is due to a 50% decrease in the number of sites, rather than to a change in the affinity of the receptor for ouabain (Fig.
Springer-Verlag, Heidelberg, pp 459-486 2. Glitsch HG (1984) BasicRes Cardiol 79: 611-619 3. Jennings RB, Schaper J, Hili ML, Steenbergen C, Jr, Reimer K (1985) Circ Res 56: 262-278 4. Katano Y, Akera T, Temma K, Kennedy RH (1984) Eur J Pharmacol105: 95-103 5. Katano Y, Kennedy RH, Stemmer PM, Temma K, Akera T (1985) Eur J Pharmacol113: 167-178 6. Kennedy RH, Akera T, Brody TM (1983) Eur J Pharmacol89: 199-209 7. Kutscherskij E, Gunther J, Mehley E (1984) Experientia 40: 812-815 8. Lin MH, Vander-Tuig JG, Romsos DR, Akera T, Leveille GA (1980) Amer J Physiol238: E 193E 199 9.
Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance by Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann, Prof. Dr. K. Greef, Prof. Dr. J. C. Skou (eds.)