Download PDF by Hugo Kubinyi, Gerhard Müller, Raimund Mannhold, Gerd Folkers: Chemogenomics in Drug Discovery: A Medicinal Chemistry

By Hugo Kubinyi, Gerhard Müller, Raimund Mannhold, Gerd Folkers

ISBN-10: 352730987X

ISBN-13: 9783527309870

Chemogenomics brings jointly the main strong techniques in sleek chemistry and biology, linking combinatorial chemistry with genomics and proteomics.The first reference dedicated to the subject, this up to date source covers all phases of the early drug discovery approach, from objective choice to compound library and lead design.With the mixed services of 20 examine teams from academia and from major pharmaceutical businesses, this publication is a must have for each drug developer and medicinal chemist employing the strong tools of chemogenomics to hurry up the drug discovery approach.

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Extra info for Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective (Methods and Principles in Medicinal Chemistry)

Sample text

Competition among research-based pharmaceutical companies is continually increasing. One company’s patent on a specific drug does not preclude other innovator companies from producing rival medicines to treat the same disease. , a novel blockbuster drug is without challenge on the market. 4 Development of exclusivity timelines in recent years [9]. The first-in-class compounds are given on the left, and the corresponding me-too drugs are given on the right. the market before the follower drug Zantac® was introduced.

Also, the compound 13 14 1 Target Family-directed Masterkeys in Chemogenomics selection criteria are changing. , an identical scaffold, front-loading of drug-likeness and structure- or mechanism-related design approaches are pursued. The concept of ‘fewer of many’ as opposed to ‘many of fewer’ offers a substantially increased likelihood of discovering viable lead compounds [17]. The current disillusion with screening huge, diverse libraries [20–23] has led to the tendency to screen libraries that are biased toward our current medicinal chemistry know-how [24, 25].

Available knowledge on the structure and/or function of target families is encoded in low-molecular-weight substructures that, upon decoration, deliver high-quality lead structures for further expansion toward viable preclinical candidates. The medicinal chemistry aspects of classification of target family-wide commonalities in ligand recognition for the design of privileged structures and the subsequent application of the masterkey concept to broadly launch into the target cluster represent a chemogenomics approach.

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Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective (Methods and Principles in Medicinal Chemistry) by Hugo Kubinyi, Gerhard Müller, Raimund Mannhold, Gerd Folkers


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