Sean Ekins's Drug Efficacy, Safety, and Biologics Discovery: Emerging PDF

By Sean Ekins

ISBN-10: 0470225556

ISBN-13: 9780470225554

This publication covers key rising applied sciences - targeted lower than concerning the subject - in pharmaceutical R & D and the way they've got considerably impacted (or are presently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating those applied sciences with drug discovery operations will gas the engine for destiny techniques. This publication cuts around the a number of components of drug discovery, every one bankruptcy authored through pioneers in that box, making for a extensive entice the chemical and organic scientists and technologists focused on drug discovery and improvement.

Show description

Read Online or Download Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools PDF

Best pharmacy books

Download e-book for kindle: Fischer Cancer Chemotherapy Handbook by David S. Fischer, Henry J. Durivage, M. Tish Knobf, Nancy

Here is a finished, but compact and useful consultant to the care and chemotherapeutic therapy of melanoma sufferers. It encompasses all significant chemotherapeutic brokers and combos, investigational and newly authorized medications, and describes their mechanisms of motion, symptoms, metabolism, dose, management, toxicity, and drug interactions and incompatibilities.

Download e-book for kindle: MCQs in Pharmacy Practice, 2nd Edition by Lilian M. Azzopardi

This ebook is designed as a revision relief, and covers issues in general featured in pharmacy undergraduate registration and licensing a number of selection examinations. This ebook is a perfect revision advisor for these getting ready to sit down a a number of selection Questions (MCQs) exam in pharmacy. It covers universal basic pharmacy perform interventions and operations and different issues ordinarily featured in examinations reminiscent of easy pharmaceutical calculations, doses, strengths, nomenclature, abbreviations, dosage kinds, specialties, alternate and everyday names, biochemical checks, category, side-effects, and customary illnesses.

Get Gene Profiles in Drug Design PDF

With the profitable mapping of the human genome, we've got entered an age of unparalleled chance during which researchers are commencing to practice this substantial repository of information to the therapy of human illness. Gene-profiling applied sciences and the idea that of individualized drugs are resulting in the advance of substances with more advantageous specificity.

Read e-book online Foundation in Pharmacy Practice PDF

This can be an introductory evaluate to pharmacy perform. This introductory evaluate to pharmacy perform is vital for first 12 months undergraduate scholars, offering an summary of the crucial pharmacy perform themes in a realistic and succinct demeanour. The textual content offers a place to begin for additional research and is facilitated through standard signposting and referencing to precise texts.

Additional info for Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools

Example text

Life Sci 1998;62:1055–63. 14. Azuma Y, Date K, Ohno K, Matsushiro S, Nobuhara Y, Yamada T. NTE-122, an acyl-coa:cholesterol acyltransferase inhibitor, prevents the progression of atherogenesis in cholesterol-fed rabbits. Jpn J Pharmacol 2001;86:120–3. 15. Azuma Y, Kawasaki T, Ikemoto K, Obata K, Ohno K, Sajiki N, et al. Cholesterollowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol 1998;78:355–64. 16.

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery. Biopharm Drug Dispos 2002;23:327–38. 24 FOCUS ON THE FUNDAMENTALS 45. Shuman CF, Vrang L, Danielson UH. Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data. J Med Chem 2004;47:5953–61. 46. Vestergaard HT, Cannillo C, Frolund B, Kristiansen U. Differences in kinetics of structurally related competitive GABA(A) receptor antagonists.

Clin Transl Oncol 2008;10: 35–46. 53. Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov 2005; 4:489–99. 54. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006;354: 731–9. 55. Owczarek J, Jasinska M, Orszulak-Michalak D. Drug-induced myopathies: an overview of the possible mechanisms. Pharmacol Rep 2005;57:23–34. 56. Pessina A, Malerba I, Gribaldo L. Hematotoxicity testing by cell clonogenic assay in drug development and preclinical trials. Curr Pharm Des 2005;11:1055–65.

Download PDF sample

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools by Sean Ekins

by Joseph

Rated 4.29 of 5 – based on 9 votes