Sean Ekins's Drug Efficacy, Safety, and Biologics Discovery: Emerging PDF

By Sean Ekins

ISBN-10: 0470225556

ISBN-13: 9780470225554

This publication covers key rising applied sciences - targeted lower than concerning the subject - in pharmaceutical R & D and the way they've got considerably impacted (or are presently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating those applied sciences with drug discovery operations will gas the engine for destiny techniques. This publication cuts around the a number of components of drug discovery, every one bankruptcy authored through pioneers in that box, making for a extensive entice the chemical and organic scientists and technologists focused on drug discovery and improvement.

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Life Sci 1998;62:1055–63. 14. Azuma Y, Date K, Ohno K, Matsushiro S, Nobuhara Y, Yamada T. NTE-122, an acyl-coa:cholesterol acyltransferase inhibitor, prevents the progression of atherogenesis in cholesterol-fed rabbits. Jpn J Pharmacol 2001;86:120–3. 15. Azuma Y, Kawasaki T, Ikemoto K, Obata K, Ohno K, Sajiki N, et al. Cholesterollowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol 1998;78:355–64. 16.

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Clin Transl Oncol 2008;10: 35–46. 53. Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov 2005; 4:489–99. 54. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006;354: 731–9. 55. Owczarek J, Jasinska M, Orszulak-Michalak D. Drug-induced myopathies: an overview of the possible mechanisms. Pharmacol Rep 2005;57:23–34. 56. Pessina A, Malerba I, Gribaldo L. Hematotoxicity testing by cell clonogenic assay in drug development and preclinical trials. Curr Pharm Des 2005;11:1055–65.

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Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools by Sean Ekins


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