By M. F. Greaves
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Extra resources for Epidemiology of Leukaemia and Lymphoma. Report of the Leukaemia Research Fund International Workshop, Oxford, UK, September 1984
Incidence rates for all CL-patients and according to morphological subtype are presented in Table 1. A further subdivision of ALL patients according to 2. Epidemiological studies These studies have been performed in collaboration their initial WBC shows 30% to have a WBC^ with the DCLSG, within the Department of Epidemio- 50 x 10V1. Annual incidence rates for three age categories 0-4, logy of the Erasmus University in Rotterdam by one of 5-9, 10-14 are presented in Table 2. A. ). boys are higher in all subtypes and in almost all age In the descriptive study covering the period 1973-1979, 757 children were included: 624 with ALL, categories.
The age of primary infection is critically important in the case of the Epstein-Barr virus (EBV) for Burkitt's lymphoma (BL) and infectious mononucleosis, and in the case of the hepatitis B virus (HBV) in relation with primary liver carcinoma pathogenesis. In contrast, the age of primary infection by retroviruses (HTLV family), or papillomaviruses may not be critical in the pathogenesis of associated malignancies (see Table 1). The integration of the viral DNA or provirai DNA in the cellular DNA has been demonstrated for the HBV, the HTLV-1, HPV-16 and 18, but not for EBV, except in one BL cell-line (Namalva).
Preliminary results are available on this aspect. Table 12 shows association between ALL and HD and past eczema/dermatitis. Table 13 shows associations between other skin diseases and most of the broad types of disease other than ALL and CML. When other risk factors are examined a complex pattern is emerging of aetiological similarities and differences which make it difficult at the present time to assert that certain diseases should or should not be regarded as linked in case-clusters. TABLE 10.
Epidemiology of Leukaemia and Lymphoma. Report of the Leukaemia Research Fund International Workshop, Oxford, UK, September 1984 by M. F. Greaves