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Ann Allergy Asthma Immunol 95: 217–26. Lynch RM, Robertson R (2004). Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study. Accid Emerg Nurs 12: 10–15. Mayo-Smith MF, Cushman Jr P, Hill AJ et al. (1997). Pharmacological management of alcohol withdrawal: a meta-analysis and evidence-based practice guideline. JAMA 278: 144–51. Medicines and Healthcare Products Regulatory Agency. uk/government/ organisations/medicines-and-healthcareproducts-regulatory-agency (accessed Dec.

3 Paracetamol nomogram. Updated guidance: The first dose was previously given over 15 minutes but the duration of the initial infusion has recently been increased to 60 minutes. org) in 2012 following a review carried out by the Commission on Human Medicines, which came to the conclusion that a slower infusion rate is less likely to cause a hypersensitivity reaction without compromising the efficacy of the treatment. In addition to this, the latest recommendations are that a previous hypersensitivity reaction to acetylcysteine is also no longer a contraindication to its subsequent use.

For full and up-to-date management guidelines, see TOXBASE. DRUGS checklist for NALOXONE Dose 100 micrograms to 2 mg initially, as IV boluses Route IV/ IM/ SC/ IVI NB. e. 200 micrograms/mL). 7 mL/hour Special situations If there is no response after 10 mg naloxone, an alternative diagnosis should be considered. Be aware that reversal of opioid effect can precipitate acute withdrawal in chronic opioid users and can unmask pain where opioid is used as analgesia. Side effects: arrhythmias, nausea and vomiting, convulsions, pulmonary oedema.

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Essential Practical Prescribing by Woodfield et al.

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