By Hans Meier
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Extra info for Experimental Pharmacogenetics. Physiopathology of Heredity and Pharmacologic Responses
1 9 6 2 ) in mature1 4 obese mice is not likely to be due to increased dilu tion o f acetate-C , since the pool of endogenous acetate has been re ported to be o f the same order of magnitude in fed obese and nonobese mice (Zomzely and Mayer, 1 9 5 9 ) . Hellman et al. ( 1 9 6 2 ) also comment on the fact that in both mature obese and lean mice there was a tendency for decreased acetate 36 III. Experimental Pharmacogenetics conversion with increasing age, an observation in accord with previous findings in the rat.
Neurochemical Strain Differences Strain variations in many behavioral patterns have been mentioned previously (see above). Specifically in two strains, the C 5 7 B L / 1 0 and B A L B / c which have been carefully investigated, consistently similar results have been obtained: the C 5 7 B L / 1 0 shows more exploratory activity, less emotionality, and superiority in fighting than the B A L B / c . 995 μ-g/gm (Caspari, I 9 6 0 ) . In view of the fact that the B A L B / c strain has a heavier brain and because serotonin is selectively concentrated in the "limbic" sys tem, expression of serotonin per total brain or per gram of brain may be misleading.
Whether or not there is indeed a difference between developing and established obesity is difficult to decide, since the conclusions reached by Christophe et al. ( 1961b) were drawn from experiments in which no glucose was added to the me dium; in the presence of glucose, lipogenesis was in fact equal in both obese and non-obese animals. , 1 9 5 5 ) . T h e depressed labeling o f fatty acids observed by Hellman et al. ( 1 9 6 2 ) in mature1 4 obese mice is not likely to be due to increased dilu tion o f acetate-C , since the pool of endogenous acetate has been re ported to be o f the same order of magnitude in fed obese and nonobese mice (Zomzely and Mayer, 1 9 5 9 ) .
Experimental Pharmacogenetics. Physiopathology of Heredity and Pharmacologic Responses by Hans Meier