Explanation in Causal Inference: Methods for Mediation and by Tyler VanderWeele PDF

By Tyler VanderWeele

ISBN-10: 0199325871

ISBN-13: 9780199325870

The booklet presents an obtainable yet finished assessment of equipment for mediation and interplay. there was massive and quick methodological improvement on mediation and moderation/interaction research in the causal-inference literature during the last ten years. a lot of this fabric seems in numerous really good journals, and a few of the papers are relatively technical. There has additionally been massive curiosity in those advancements from empirical researchers within the social and biomedical sciences. besides the fact that, a lot of the cloth isn't at the moment in a layout that's obtainable to them. The publication closes those gaps by means of delivering an obtainable, accomplished, book-length insurance of mediation.

The booklet starts with a accomplished creation to mediation research, together with chapters on ideas for mediation, regression-based equipment, sensitivity research, time-to-event results, tools for a number of mediators, equipment for time-varying mediation and longitudinal information, and kin among mediation and different ideas regarding intermediates reminiscent of surrogates, crucial stratification, instrumental variables, and Mendelian randomization. the second one a part of the ebook issues interplay or "moderation," together with suggestions for interplay, statistical interplay, confounding and interplay, mechanistic interplay, bias research for interplay, interplay in genetic reviews, and tool and sample-size calculation for interplay. the ultimate a part of the ebook offers entire dialogue in regards to the relationships among mediation and interplay and unites those innovations inside a unmarried framework. This ultimate half additionally offers an creation to spillover results or social interplay, concluding with a dialogue of social-network analyses.

The publication is written to be obtainable to someone with a simple wisdom of data. finished appendices supply extra technical info for the reader. utilized empirical examples from a number of fields are given all through. software program implementation in SAS, Stata, SPSS, and R is equipped. The ebook may be obtainable to scholars and researchers who've accomplished a first-year graduate series in quantitative equipment in a single of the social- or biomedical-sciences disciplines. The booklet will merely presuppose familiarity with linear and logistic regression, and will very likely be used as a complicated undergraduate ebook to boot.

Show description

Read Online or Download Explanation in Causal Inference: Methods for Mediation and Interaction PDF

Similar epidemiology books

Download e-book for kindle: Veterinary Clinical Epidemiology: A Problem-Oriented by Ronald D. Smith

Ways and strategies of medical epidemiology became more and more admired in veterinary literature. This moment variation of Veterinary medical Epidemiology: A Problem-Oriented technique displays the expanding attractiveness of the position of medical epidemiology through targeting the appliance of epidemiologic rules and strategies of difficulties on a regular basis confronted by means of veterinary practitioners.

Read e-book online Epidemiology for the Uninitiated PDF

This perennial bestseller is a perfect introductions to epidemiology in health and wellbeing care. The fifith editon keeps the book's simplicity and brevity, even as supplying the reader with the center components of epidemiology wanted in wellbeing and fitness care perform and study. The textual content has been revised all through, with new examples brought to deliver the e-book correct modern.

New PDF release: Medical Geography

The major textual content within the box, this complete booklet stories geographic methods to learning illness and public overall healthiness matters around the globe. It provides state of the art concepts of spatial and social research and explores their relevance for realizing cultural and political ecology, disorder structures, and well-being advertising.

Get Epidemiology of Peripheral Vascular Disease PDF

Significant epidemiologists from the united kingdom, united states and Europe give a contribution to the 1st ever, a lot wanted complete evaluate of the epidemiology of peripheral vascular illness within the reduce limbs.

Extra resources for Explanation in Causal Inference: Methods for Mediation and Interaction

Example text

Techniques for assessing these so-called “qualitative” or “crossover” interactions will also be discussed in Chapter 9 and are useful in this regard. We will describe there, for example, a breast cancer treatment setting in which, for young patients under age 50 with low progesterone receptor levels, treatment without tamoxifen led to higher proportions who were disease-free at 3 years, but for all other groups (who were either older or had higher progesterone receptor levels, or both), treatment with tamoxifen led to higher proportions who were disease-free at 3 years.

For example, there might be (a) social and biological factors, such as income and hypertension status (C1 ), that affect decisions about the level of treatment (A) and the work activity outcome (Y) or (b) other factors, such as neighborhood of residence or alcohol consumption (C2 ), that affect both the level of drug use (M) and the working activity outcome (Y). For the effect estimates to have a causal interpretation, control must be made for the confounding variables. In order to be able to estimate the controlled direct effect using the formula above, two assumptions are needed.

1. Motivations for Assessing Mediation Methods for mediation help understand the mechanisms, pathways, and intermediates whereby a cause affects an outcome. There are a number of motivations for wanting to understand the phenomenon of mediation. In some instances, the motivation may principally be simply explanation and understanding. For example, in Chapter 2 we will consider an example from genetic epidemiology in which genetic variants were found to be associated with both smoking behavior and lung cancer.

Download PDF sample

Explanation in Causal Inference: Methods for Mediation and Interaction by Tyler VanderWeele


by Kenneth
4.4

Rated 4.54 of 5 – based on 40 votes