Read e-book online Flow Cytometry in Drug Discovery and Development PDF

By Virginia Litwin, Philip Marder

ISBN-10: 0470433566

ISBN-13: 9780470433560

ISBN-10: 0470910089

ISBN-13: 9780470910085

This booklet covers the original software of move cytometry in drug discovery and improvement. the 1st part contains introductory chapters, one on movement cytometry and one on biomarkers, in addition to a bankruptcy on contemporary advances in stream cytometry. the second one part specializes in the original demanding situations and additional advantages linked to using movement cytometry within the drug improvement method. The 3rd part encompasses a unmarried bankruptcy proposing a close dialogue of validation issues and regulatory compliance matters linked to drug development.Content:
Chapter 1 creation to movement Cytometry (pages 3–21): Elizabeth Raveche, Fatima Abbasi, Yao Yuan, Erica Salerno, Siddha Kasar and Gerald E. Marti
Chapter 2 contemporary Advances in movement Cytometry: structures, instruments, and demanding situations for info research (pages 23–54): Paul J. Smith, Roy Edward and Rachel J. Errington
Chapter three creation to Biomarkers (pages 55–68): Ole Vesterqvist and Manjula P. Reddy
Chapter four HTS move Cytometry, Small?Molecule Discovery, and the NIH Molecular Libraries Initiative (pages 71–97): Larry A. Sklar and Bruce S. Edwards
Chapter five A Multiparameter method of mobilephone Cycle research as a customary instrument in Oncology Drug Discovery (pages 99–122): Carmen Raventos?Suarez and Byron H. Long
Chapter 6 movement Cytometry in Preclinical Toxicology/Safety evaluate (pages 123–150): David McFarland and Kristi R. Harkins
Chapter 7 Use of stream Cytometry to check Drug goal Inhibition in Laboratory Animals and in Early?Phase medical Trials (pages 151–168): David W. Hedley
Chapter eight CD4 T cellphone checks in overview of HIV Therapeutics (pages 169–187): Thomas N. Denny, Raul Louzao, John Wong and Brooke Walker
Chapter nine tracking the mobile parts of the Immune approach in the course of scientific Trials: A Translational medication process (pages 189–203): Virginia Litwin and James Andahazy
Chapter 10 Immunogenicity checking out utilizing circulation Cytometry (pages 205–223): Denise M. O'Hara and Valerie Theobald
Chapter eleven Pharmacokinetics by means of move Cytometry: ideas for improvement and Validation of stream Cytometric process for Pharmacokinetic stories (pages 225–240): Yuanxin Xu and Susan M. Richards
Chapter 12 Regulatory Compliance and procedure Validation (pages 243–266): Carla G. Hill, Dianna Y. Wu, John Ferbas, Virginia Litwin and Manjula P. Reddy
Chapter thirteen device Validation for Regulated reports (pages 267–277): John Ferbas and Michelle J. Schroeder
Chapter 14 chance country Modeling: a brand new Paradigm for Cytometric research (pages 281–302): C. Bruce Bagwell
Chapter 15 Phospho move Cytometry: Single?Cell Signaling Networks in Next?Generation Drug Discovery and sufferer Stratification (pages 303–334): Peter O. Krutzik, Sean C. Bendall, Matthew B. Hale, Jonathan M. Irish and Garry P. Nolan

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Recent advances in gene and small molecule delivery modalities and automated systems for cell manipulation have supported such approaches [9]. Flow cytometry stands alongside a range of specialized techniques for performing cell-based assays in drug discovery and even has an expanding role in profiling toxicology for ADME/Tox (absorption, distribution, metabolism, excretion, and toxicology) evaluations. With its unique capacity to assess the dimensions of heterogeneity in complex cellular systems, it continually finds new areas of application.

Laser-scanning cytometry: a new instrumentation with many applications. Exp. Cell Res. 1999;249 (1):1–12. 17. , Ratajczak MZ. The ImageStream system: a key step to a new era in imaging. Folia Histochem. Cytobiol. 2007;45(4):279–290. 18. Robinson JP. Comparative overview of flow and image cytometry. Curr. Protoc. Cytom. 1. 19. Herzenberg LA, Parks D, Sahaf B, Perez O, Roederer M. The history and future of the fluorescence activated cell sorter and flow cytometry: a view from Stanford. Clin. Chem.

Cytom. 1. 19. Herzenberg LA, Parks D, Sahaf B, Perez O, Roederer M. The history and future of the fluorescence activated cell sorter and flow cytometry: a view from Stanford. Clin. Chem. 2002;48(10):1819–1827. 20. Shapiro HM. Trends and developments in flow cytometry instrumentation. Ann. Y. Acad. Sci. 1993;677: 155–166. 21. Loken MR, Stall AM. Flow cytometry as an analytical and preparative tool in immunology. J. Immunol. Methods 1982;50(3):R85–R112. 22. Dean PN, Jett JH. Mathematical analysis of DNA distributions derived from flow microfluorometry.

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Flow Cytometry in Drug Discovery and Development by Virginia Litwin, Philip Marder

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