Download PDF by P. Joliès (auth.), Prof. Dr. P. Jollès (eds.): Lysozymes: Model Enzymes in Biochemistry and Biology

By P. Joliès (auth.), Prof. Dr. P. Jollès (eds.)

ISBN-10: 303489225X

ISBN-13: 9783034892254

ISBN-10: 3034899521

ISBN-13: 9783034899529

Greater than seventy years after Fleming's discovery of lysozyme, this enzyme maintains to play a vital position as a version enzyme in protein chemistry, enzymology, crystallography, molecular biology and genetics, immunology and in addition in evolutionary biology. The classical consultant of this common enzyme relations is the chicken egg-white lysozyme. bird (c)-type lysozymes have additionally been characterised in lots of different animals together with mammals, reptiles and invertebrates. in addition to this c-type lysozyme, different unique forms, differing at the foundation of structural, catalytic and immunological critera, were defined to boot, those in birds, phages, micro organism, fungi, invertebrates and crops. The specificity, although, of some of these enzymes is similar: they cleave a ?-glycosidic bond among the C-1 of N-acetylmuramic acid and the C-4 of N-acetylglucosamine of the bacterial peptidoglycan. during this quantity particular emphasis is put on effects got over the past ten years. Lysozymes are on no account simply defence or, from time to time, digestion enzymes. in truth, peptidoglycan fragments published by means of the lytic motion of this enzyme family members can set off the synthesis of immunostimulating or antibacterial components, and a bunch of different unforeseen, organic reactions might be provoked by means of lysozymes to boot. As Fleming has prophesized: ''We shall listen extra approximately lysozyme''.

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Greater than seventy years after Fleming's discovery of lysozyme, this enzyme keeps to play a vital position as a version enzyme in protein chemistry, enzymology, crystallography, molecular biology and genetics, immunology and in addition in evolutionary biology. The classical consultant of this frequent enzyme kin is the chicken egg-white lysozyme.

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J. Mol. Evol. 21: 97 - 111. G. W. (1995) The refined structures of goose lysozyme and its complex with a bound trisaccharide show that the "goose-type" Iysozymes lack a catalytic aspartate residue. J. Mol. Bioi. 245: 54-68. M. e. (1986) Evolutionary shift in the site of cleavage of pre lysozyme. J. Bioi. Chern. 261: 2309- 2313. e. M. (1993) Evolution of rodent Iysozymes: Isolation and sequence of the rat lysozyme genes. Mol. Phyla. Evol. 2: 65-75. Discovery of several families of lysozymes Lysozymes: Model Enzymes in Biochemistry and Biology ed.

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238: 2698-2707. E. and McMurry, S. (1967) Purification and characterization of a lysozyme from goose egg white. Biochem. Biophys. Res. Commun. 26: 38-42. L. (1988) Vertebrate Paleontology and Evolution. H. , New York. , SamakovIis, C. and Hultmark, D. (1994) The lysozyme locus in Drosophila melanogaster: An expanded gene family adapted for expression in the digestive tract. Mol. Gen. Genet. 242: 152-162. , Grinde, B. and Jolles, P. (1991) cDNA and amino acid sequences of rainbow trout (Oncorhynchus mykiss) Iysozymes and their implications for the evolution of lysozyme and lactalbumin.

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Lysozymes: Model Enzymes in Biochemistry and Biology by P. Joliès (auth.), Prof. Dr. P. Jollès (eds.)


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