By Michael J. Rathbone
Describing formula demanding situations and their ideas within the layout, improvement, and commercialization of modified-release medications supply platforms, this ebook includes 80 papers that overview fresh advancements in layout and production innovations. It comprises unique descriptions of prolonged free up drug items for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. apart from the ultimate part addressing regulatory concerns, every one part covers a selected course for drug supply and opens with an outline of the anatomical, physiological, and pharmaceutical fundamentals of every path earlier than relocating directly to hide particular applied sciences.
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Extra resources for Modified-Release Drug Delivery Technology (Drugs and the Pharmaceutical Sciences)
Pharm Res 15:11– 22, 1998. 7. R Lobenberg, GL Amidon. Modern bioavailability, bioequivalence and biopharmaceutics classification system: new scientific approaches to international regulatory standards. Eur J Pharm Biopharm 50:3–12, 2000. 8. IR Wilding, AJ Coupe, SS Davis. The role of γ-scintigraphy in oral drug delivery. Adv Drug Del Rev 46:103–124, 2001. 9. SS Davis, FN Christensen, JG Hardy. The intestinal transit of pharmaceutical dosage forms. Gut 27:886–892, 1986. 10. CT Rhodes, SC Porter.
The role of γ-scintigraphy in oral drug delivery. Adv Drug Del Rev 46:103–124, 2001. 9. SS Davis, FN Christensen, JG Hardy. The intestinal transit of pharmaceutical dosage forms. Gut 27:886–892, 1986. 10. CT Rhodes, SC Porter. Coatings for controlled-release drug delivery systems. Drug Dev Ind Pharm 24:1139–1154, 1998. 11. VRS Uppoor. Regulatory perspectives on in vitro (dissolution)/in vivo (bioavailability) correlations. J Control Rel 72:127–132, 2001. 12. V Lenaerts, I Moussa, Y Dumoulin, F Mebsout, F Chouinard, P Szabo, MA Mateescu, L Cartilier, R Marchessault.
Table 6 Summary of the Clinical Trial Formulations Based on COSRx Technology Formulation Ingredient Nifedipine, USP Guar gum, low viscosity (Tic-LV NF) Polyvinylpyrrolidone (Plasdone K-25) Silicon dioxide (Syloid 244 FP) Lactose monohydrate (Fast Flo) Carboxyvinyl polymer (Carbopol 974P) Magnesium stearate, NF Eudragit RL/RS Coating (1 : 9) Copyright © 2003 Marcel Dekker, Inc. 5 2 MASRx and COSRx Sustained-Release Technology 31 Figure 5 Effect of adjusted tablet weight on nifedipine release from guar-gum-based formulation A, 300 mg (ᮀ), 275 mg (᭝), 250 mg (᭛), and Procardia XL 30 mg (᭺).
Modified-Release Drug Delivery Technology (Drugs and the Pharmaceutical Sciences) by Michael J. Rathbone