Get Neuropeptide Y and Drug Development PDF

By Lars Grundemar, Stephen R. Bloom

ISBN-10: 0080537456

ISBN-13: 9780080537450

ISBN-10: 0123049903

ISBN-13: 9780123049902

Neuropeptide Y (NPY) is a ubiquitous and demanding messenger within the anxious approach, with quite a lot of physiological roles. it really is interested by the physique strength stability and is without doubt one of the so much powerful stimuli of foodstuff consumption identified. NPY additionally acts to control relevant and peripheral autonomic functions.This publication, written via educational and business specialists within the box, hyperlinks the newest easy experimental wisdom approximately NPY and its receptors with parts of medical importance.This ebook could be of curiosity to these operating in all components of analysis laid low with NPY, comparable to foodstuff consumption and effort homeostasis, cardiovascular rules and G-protein-coupled receptors, in addition to these drawn to the improvement of gear as NPY objectives. Key gains* The hypothalamic position of NPY and its courting with consuming issues and diabetes* The sympathetic anxious approach function of NPY and its involvement in cardiovascular problems* Characterization of NPY receptor varieties and their mind distribution, molecular biology and pharmacology* improvement of peptide and non-peptide receptor antagonists

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The obese {ob/ob) mouse and the Zucker {fa/fd) rat are unable to increase their thermogenic activity as a consequence of increases in feeding or cold exposure (Himms Hagen and Desautels, 1978; Holt etaL, 1983). Indeed a recent study demonstrated that a reduction in the mass of BAT (by toxigene-mediated ablation) increases susceptibility to diet-induced obesity and its accompanying disorders such as insulin resistance and hyperlipidemia (Hamann et aL, 1996). NPY injection (30-156 pmol) elevated the respiratory quotient, which is indicative of oxidation of carbohydrate, and storage of energy as fat (Menendez et aL, 1990).

E & Britton, K . T (1993) Anxiolytic-like action of neuropeptide Y: mediation by Y l receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology 8, 357-363. Y. L. (1988) Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester. J. BioL Chem. 263, 6288-6295. Himms Hagen, J. & Desautels, M. (1978) A mitochondrial defect in brown adipose tissue of the obese [ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding.

Tolerance does develop to other known stimulators of feeding (Smith et aL, 1994). The gain in body weight following chronic administration of NPY was disproportionate to the caloric consumption of the animals, suggesting an effect of NPY on peripheral metabolism separate from its orexigenic properties. Further studies have revealed a diverse range of actions of NPY including effects on themogenesis and lipogenesis, independent of its effect on feeding. Such observations have led to the suggestion that NPY may be involved in the pathophysiology of eating disorders such as obesity, which is discussed later in this chapter.

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Neuropeptide Y and Drug Development by Lars Grundemar, Stephen R. Bloom

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