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By Doris H. (Ed.) Clouet

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1976) proposed the existence of mu, kappa, and sigma opioid receptors based on observed differences in pharmacological profiles of drugs seen with variably selective opioid agonists and antagonists. Other groups have provided evidence for the delta subtype (Hughes et al. 1975). The mu opioid receptor has been extensively characterized (Lord et al. 1976; Lord et al. 1977; Chang et al. 1979; Chang and Cuatrecasas 1981). Classical opioid effects, such as analgesia induced by morphine and its congeners, are thought to be mediated by the mu opioid receptor, which preferentially binds the levorotatory isomer.

L. Stereoisomers of ( H)-N-allylnormetazocine bind to different sites in mouse brain. J Pharmacol Exp Ther 231:539, 1984. E. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197:517-532, 1976. M. The opiomelanotropinergic neuronal and endocrine systems. Peptides (Fayetteville) 3:353-395, 1982. ; and Quirion, R. Evidence for an endogenous CNS ligand for the PCP receptor. , eds. Proceedings of the Eighth American Peptide Symposium.

Proc Natl Acad Sci USA 80:6703-6707, 1983. , and Cook, L. Sigma opiates and certain antipsychotic drugs mutually inhibit (+)3H-SKF-10,047 and 3H-haloperidol binding in guinea-pig brain membranes. Proc Natl Acad Sci USA 81:5618-5621, 1984. G. Discriminative stimulus effects of cyclazocine in the rat. J Pharmacol Exp Ther 212:368-376, 1980. S. Visualization of opiate receptor upregulation by light microscopy autoradiography. Proc Natl Acad Sci USA 81:3893-3897, 1984. ; and Lazdunski, M. affinity for the PCP receptor in rat brain.

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Phencyclidine: An update by Doris H. (Ed.) Clouet


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